Endocrine Abstracts

The diagnosis of hypogonadism in a young person represents reduced sex steroid production and subfertility.Optimising sex steroid replacement both in terms of preparation and dose occurs after pubertal induction. Clinical practice has changed in the UK in respect to females. The management of subclinical hypogonadism and benefits of testosterone replacement in male cancer survivors and klinefelter syndrome remain unclear. The endocrinologist needs to nav...

The biggest achievement of bariatric surgery was to demonstrate that obesity co-morbidity improve or even reverse with long-term weight control. This evidence was achieved with the Swedish Obesity Study for mortality and diabetes incidence.Diabetes resolution rates range from 55 to 96% depending on the surgical procedure and length of follow-up. Diabetes improvement or resolution almost reaching the 100%. The type of surgery seems to play a role in diabe...

The effects of cancer therapy on pituitary and thyroid function evolve over many years and therefore careful long term screening strategies are required. Knowledge of the initial cancer diagnosis, age at diagnosis, radiation field, radiation dose and duration of follow up can aid identification of survivors most at risk.Cranial irradiation to the hypothalamic pituitary axis increases the risk of pituitary dysfunction. The most common pituitary hormone to...

Primary hyperparathyroidism (PHPT) belongs to the most common endocrine disorders. It is increasingly reported in patients without any symptoms and hypercalcemia. In the 3rd international workshop on asymptomatic PHPT (Orlando 2008) the normocalcemic PHPT was recognised as a stand-alone entity that needs more attention.Aim: The purpose of this study is to analyse data from patients with normocalcemic asymptomatic PHPT and to create an effective source da...

Diabetes mellitus is a disease with one of the greatest burdens to both the economy and the individual. Monogenic diabetes mellitus, responsible for neonatal diabetes mellitus and maturity-onset diabetes of the young (MODY), results from one mutation in a single gene. Many of these genes play a role in pancreatic development and their variants can increase risk of type 2 diabetes mellitus (T2DM). Therefore, while the monogenic form of diabetes contributes the least to the over...

Objective: Determination of changes in metabolic status and vitamin D, osteoprotegerin concentrations in obese children.Methods: We examined 212 children in the University Hospital from 2016 to 2018 yrs. Their anthropometric parameters (body mass index (BMI)) were determined. Blood levels of vitamin D, OPG, insulin were determined. In the biochemical blood test, the parameters of uric acid, glucose were evaluated. All children were divided into 2 groups:...

Objective: Determination of changes in metabolic status and osteoprotegerin concentrations in obese children.Methods: We examined 221 children in the University Hospital (Minsk) from 2017 to 2019 yrs. Their anthropometric parameters (height, weight, body mass index (BMI)) were determined. Blood levels of osteoprotegerin (OPG), insulin were determined. In the biochemical blood test, the parameters of uric acid, insulin were evaluated. All children were di...

Objective: Determination of changes in metabolic status and vitamin D, osteoprotegerin concentrations in obese children.Methods: We examined 221 children in the University Hospital (Minsk) from 2017 to 2019 yrs. Their anthropometric parameters (height, weight, body mass index (BMI)) were determined. Blood levels of vitamin D, osteoprotegerin (OPG), insulin were determined. In the biochemical blood test, the parameters of uric acid, glucose were evaluated...

Aim: To evaluate the current service provisions and provide action plan for improvement within the YAE service.Methods: A friends and family questionnaire given to all patients attending the YAE service from October 2018 – January 2019. Survey questions included: whether they thought this was a good clinic for friends and family to be looked after in, what we did well and what we could do better. For YA patients transferring from children’s s...

Primary hyperthyroidism (PHPT) is one of the diseases which are usually diagnosed in asymptomatic period nowadays. Even though considerable success was achieved, in some cases PHPT is not found out before complications were developed. A prospective study focuses on diagnostics and therapy of PHPT has been in progress at two tertiary centers of endocrinology in the Czech Republic since January 1st, 2007, with early diagnosis of PHPT being one of its aims. In a 6-year period, th...